cyclosporine a การใช้

• Cyclosporine A is a current topic of research; preliminary results have shown it to be effective.
• The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione.
• The disease can be treated to slow down the development by use of cyclosporine A and ACE inhibitors, but not be stopped.
• This protein can bind to cells derived from T-and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.
• Fruit extract from the plant had deep inhibitory effects on airway inflammation caused by allergic inflammation and asthma when combined with cyclosporine A.
• Later studies led to the establishment of rapamycin as a major immunosuppressant against transplant rejection, along with cyclosporine A . By using rapamycin in combination with cyclosporin A, it enhanced the rejection prevention in renal transplantation.
• More than 20 years ago in November1983 the US-FDA approved Etoposide ( ex Bristol-Myers, now Bristol-Myers Squibb Corp . ) and Cyclosporine A ( ex Sandoz, now Novartis Corp . ).
• Species of " Beauveria " and " Metarhizium " show some promise as biological control agents against pest insects . " Tolypocladium inflatum " was the original source of cyclosporine A, used as a drug to prevent rejection of organ transplants.
• What is less known however is that the individual behind the original discovery of the biological activity of etoposide ( discovered October 21, 1966 ) and cyclosporine A ( discovered January 31, 1972 ) was the doctor-scientist Hartmann F . St鋒elin, M . D .-a Swiss pharmacologist with an outstanding record in basic and applied cancer and immunology research.
• This screen led St鋒elin, after he had discovered the nonmyelotoxic immunosuppressant ovalicin in a similar screen, on January 31, 1972 to the discovery of the potent biological activity of cyclosporine A  the drug which revolutionized organ transplantation in the 1970's ( J . F . Borel, C . Feurer, H . U . Gubler, H . St鋒elin " Biological effects of cyclosporin A : a new antilymphocytic agent " Agents Actions 6 : 468-475, 1976-a subsequent citation classic CC / 6 : 16-16, February 6, 1984 ).